We work in an age of climatic, political, and economic extremes, shaped by a building industry that still extracts, wastes, and demolishes by default. Integrative Design | Extremes challenges this linear model by advancing circular, regenerative architecture grounded in material care. Using outer space extremes as a lens, we move across scales – from cities and ecologies to buildings, materials, and microbes. We see architecture as stewardship across the earth-space continuum, where design must prioritize reuse, repair, adaptation, and disassembly. Through research, teaching, and interdisciplinary collaboration, we develop resilient, low-waste systems that turn architecture into a lasting social and ecological resource.